A Simple Method for Automated Allele Binning in Microsatellite Markers
نویسندگان
چکیده
منابع مشابه
A simple method for automated allele binning in microsatellite markers.
High-throughput fluorescent genotyping requires a considerable amount of automation for accurate and efficient processing of genetic markers. Automated DNA sequencers and corresponding software products are commercially available that contribute substantially to increased throughput rates for large-scale genotyping projects. However, some conceptually simple tasks still require time-consuming m...
متن کاملTANDEM: integrating automated allele binning into genetics and genomics workflows
SUMMARY Computer programs for the statistical analysis of microsatellite data use allele length variation to infer, e.g. population genetic parameters, to detect quantitative trait loci or selective sweeps. However, observed allele lengths are usually inaccurate and may deviate from the expected periodicity of repeats. The common practice of rounding to the nearest whole number frequently resul...
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Microsatellite markers are widely used for genetic analysis in biomedical research, agriculture, population and evolutionary biology, as well as for forensics and diagnostics. Advances in laboratory automation and data collection have increased the throughput and have reduced the cost of large-scale genotyping. One step in the measurement process that still needs improvement is “allele calling”...
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Molecular simulations intended to compute equilibrium properties are often initiated from configurations that are highly atypical of equilibrium samples, a practice which can generate a distinct initial transient in mechanical observables computed from the simulation trajectory. Traditional practice in simulation data analysis recommends this initial portion be discarded to equilibration, but n...
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Background Despite recent progress in fast cardiac imaging, respiratory motion remains a challenging problem, usually leading to poor image quality when scanning poor breath-holder patients or acquiring high spatial resolution images. Today respiratory motion is compensated using navigators or external physiological sensors and can result in decreased scan efficiency and increased setup complex...
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ژورنال
عنوان ژورنال: Genome Research
سال: 1997
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.7.11.1104